We need to keep eye on http://elixirgen.com/ This is new company so not alto of detail but they are trying.

https://lejeuneusa.org/blog/curing-down-syndrome#.Vm8-o0orJpg

http://elixirgen.com/

http://www.nature.com/news/researchers-turn-off-down-s-syndrome-genes-1.13406

I will keep this in my alert list.

http://hereandnow.wbur.org/2013/07/17/therapy-down-syndrome