What if mRNA could be a drug – Moderna Therapeutics

Modified messenger RNA (mRNA) Therapeutics™ can be encoded for virtually any known protein and designed to be taken up by the cells in specific tissues and organs. Our novel chemistry enables mRNA to elude the body’s innate immune response. Once delivered, like native mRNA in healthy individuals, mRNA Therapeutics™ act as cellular software directing ribosomes to express proteins or antibodies within targeted tissues – and have the power to catalyze the expression of hundreds to thousands of proteins for each mRNA molecule.

mRNA drugs drive therapeutic benefit by virtue of the proteins they encode. Because of mRNA’s ability to direct transient, dose-dependent intracellular expression of protein, we are witnessing the creation of a series of new drug modalities:

  • Secreted proteins
  • Antibodies
  • Combination therapy
  • Un-druggable intracellular pathways
  • Regenerative medicine
  • Vaccines


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